宋波

个人信息Personal Information

副教授

博士生导师

硕士生导师

性别:男

毕业院校:大连化物所

学位:博士

所在单位:化学学院

学科:分析化学

办公地点:大连理工大学西部校区化工综合楼D313

联系方式:+86-411-84986042

电子邮箱:bo.song@dlut.edu.cn

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A novel heterobimetallic Ru(II)-Gd(III) complex-based magnetoluminescent agent for MR and luminescence imaging

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论文类型:期刊论文

发表时间:2015-11-04

发表刊物:RSC ADVANCES

收录刊物:SCIE、EI、Scopus

卷号:5

期号:117

页面范围:96525-96531

ISSN号:2046-2069

摘要:A novel heterobimetallic ruthenium(II)-gadolinium(III) complex, Ru-Gd, comprising a luminescent Ru(II) complex, [Ru(bpy)(2)(phen)](2+) (bpy: 2,2'-bipyridine; phen: 1,10-phenanthroline), and a Gd(III) complex, DOTA-Gd3+ (DOTA: 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), has been designed and synthesized as a magnetoluminescent dual-modal imaging agent. The heterobimetallic complex Ru-Gd is water-soluble, biocompatible with low cytotoxicity, strongly luminescent with a long luminescence lifetime and a large Stokes shift, and has comparable longitudinal relaxivity r(1) (4.71 mM(-1) s(-1)), which enable the complex to be suitable for luminescence bioimaging and T-1-weighted MR imaging. Using Ru-Gd as a contrast agent, the T-1-weighted MRI of a Kunming (KM) mouse was successfully carried out. The results demonstrated the availability and validity of our approach for the development of magnetoluminescent dual-modal imaging agents.