宋波

个人信息Personal Information

副教授

博士生导师

硕士生导师

性别:男

毕业院校:大连化物所

学位:博士

所在单位:化学学院

学科:分析化学

办公地点:大连理工大学西部校区化工综合楼D313

联系方式:+86-411-84986042

电子邮箱:bo.song@dlut.edu.cn

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A functional ruthenium(II) complex for imaging biothiols in living bodies

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论文类型:期刊论文

发表时间:2015-05-07

发表刊物:DALTON TRANSACTIONS

收录刊物:SCIE、EI、PubMed、Scopus

卷号:44

期号:17

页面范围:8278-8283

ISSN号:1477-9226

摘要:A unique ruthenium(II) complex, [Ru(bpy)(2)(DNS-bpy)](PF6)(2) [bpy: 2,2'-bipyridine, DNS-bpy: 4-(2,4-dinitrophenylthio)-2,2'-bipyridine], that can act as a probe for the recognition and luminescence sensing of biothiols has been designed and synthesized. Due to the presence of effective photo-induced electron transfer (PET) from the potent electron donor (Ru-bpy centre) to the strong electron acceptor (2,4-dinitrophenyl moiety), the Ru(II) complex itself is weakly luminescent. Reaction of [Ru(bpy)(2)(DNS-bpy)](PF6)(2) with biothiols leads to the replacement of the 2,4-dinitrophenyl moiety by biothiols, which results in the loss of PET within the complex, to allow recovery of the MLCT-based emission of the Ru(II) complex with an 80-fold increase in luminescence intensity. Taking advantage of the high specificity and sensitivity, and the excellent photophysical properties of Ru(II) complexes, [Ru(bpy)(2)(DNS-bpy)](PF6)(2) was successfully applied to the luminescence imaging of biothiols in living Daphnia magna. The results demonstrated the practical applicability of [Ru(bpy)(2)(DNS-bpy)](PF6)(2) as a luminescent probe for the monitoring of biothiols in living bodies.