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论文类型：期刊论文

发表时间：2016-10-12

发表刊物：ACS APPLIED MATERIALS & INTERFACES

收录刊物：SCIE、EI、PubMed、Scopus

卷号：8

期号：40

页面范围：26570-26577

ISSN号：1944-8244

关键字：platelet-repellent surfaces; polyphenols; micropattern; platelet adhesion detection; antiplatelet drug

摘要：Surface patterning provides a powerful tool to the diagnosis of platelet adhesion. However, the current methodologies of constructing platelet-patterned surfaces require laborious and complicated steps. Herein, a novel and simple platelet-repellent surface was reported by metal (Fe3+ ions)-polyphenol (tannic acid, TA) coordination interaction. The platelet repellent effect was significantly better than that of poly(ethylene glycol) (PEG) in a long-term. Moreover, the platelet-repellent behavior could extend to other polyphenols-functionalized surfaces. On the basis of these observations, a TA-based micropattern was fabricated in situ by one-step microcontact printing for well-defined platelet adhesion, which can effectively avoid the traditional introduction of inert hydrophilic polymers and bioactive ligands. Afterward, the TA-based micropattern was applied to monitor the adhesion of defective platelets treated with an antiplatelet drug (tirofiban). This work provided a facile, versatile, and environmentally friendly strategy to construct platelet-repellent polyphenolic surfaces and their micropattern. We expect that this simple micropattern could act as a low-cost and label-free platform for biomaterials and biosensors, and could be widely used in the clinical diagnoses of platelet adhesive functions and-the evaluation of antiplatelet therapies.