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论文类型： 期刊论文

发表时间： 2018-02-01

发表刊物： DYES AND PIGMENTS

收录刊物： SCIE、EI

卷号： 149

页面范围： 633-638

ISSN号： 0143-7208

关键字： Cyanine dye; Mitochondria; Photosensitizer; Photodynamic therapy; Cancer cell; Apoptosis

摘要： Mitochondria play essential roles in cellular energy supply and produce 90% of reactive oxygen species. A mitochondrial targeted photosensitizer is greatly beneficial to improve the photodynamic therapeutic effect via apoptosis. Herein bromo-pentamethine dyes (lambda(abs) > 650 nm) are designed as mitochondria-localized anticancer photosensitizers. Cell experiments demonstrate that Cy-Br localizes in mitochondria with very low cytotoxicity in dark, and induces cancer cells apoptosis under light with IC50 as low as 62 nM, much better than commercial Ce6 (3706 nM). Bromo-group could enhance the quantum yield of reactive oxygen species. The high efficiency might provide a new clue to develop new photosensitizers.