Title of Paper:Synthesis of pyridinium N-chloramines for antibacterial applications

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Date of Publication:2017-01-25

Journal:TETRAHEDRON LETTERS

Included Journals:SCIE、Scopus

Volume:58

Issue:4

Page Number:321-325

ISSN No.:0040-4039

Key Words:N-Chloramine; Chemical synthesis; Pyridinium salt; Bactericidal activity

Abstract:To develop more efficacious antibacterial agents, a new type of cationic N-chloramines that contain a pyridinium moiety and a N-chloramine moiety covalently linked via an alkyl chain were prepared and characterized. Preliminary assays indicated that 1) the compound with a propylidene linker exhibited higher antibacterial activity than the quaternary ammonium counterpart; 2) the chain length of the alkyl linker had major effects on their biocidal properties. Our results may inspire exploration of more pyridinium N-chloramines for antibacterial applications. (C) 2016 Elsevier Ltd. All rights reserved.