Title of Paper:Synthesis of quaternary phosphonium N-chloramine biocides for antimicrobial applications

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Date of Publication:2017-01-01

Journal:RSC ADVANCES

Included Journals:SCIE

Volume:7

Issue:22

Page Number:13244-13249

ISSN No.:2046-2069

Abstract:The recently developed quaternary ammonium (QA) N-chloramine has been proved to be a promising "composite" biocide with drastically boosted antibacterial efficacy afforded by the QA moiety. In this work, a series of quaternary phosphonium (QP) N-chloramine biocides, covalently combining an N-chloramine moiety and a QP moiety via varied aliphatic methylene units, were synthesized by means of multi-step chemical reactions. Preliminary antibacterial tests against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) showed that the synthetic QP N-chloramine exhibited distinctively higher biocidal efficacy than the QA counterpart. Furthermore, bactericidal tests also indicated that QP N-chloramine with a linker of -(CH2)(12)-showed the highest biocidal efficacy, suggesting synergistic action between the N-chloramine moiety and QP moiety.