Release Time:2019-03-12  Hits:

Indexed by: Journal Article

Date of Publication: 2018-01-01

Journal: JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY

Included Journals: Scopus、EI、SCIE

Volume: 39

Issue: 3

Page Number: 367-374

ISSN: 0193-2691

Key Words: Controlled release; curcumin; hydrophobic calcium alginate; Pickering emulsion; stability

Abstract: pH-responsive Pickering emulsions were prepared, taking the hydrophobic modified calcium alginate nanoparticles (MCA) of pH sensitivity as emulsifiers. The MCAs were obtained via gelation between Ca2+ in emulsion and alginate sodium that reacted with diacetone acrylamide since alginate sodium was too hydrophilic to be used as a stabilizer. The effect of MCA characteristics, Ca2+ content, and pH on the preparation and property of emulsion was evaluated. Then, the released behaviors of MCA-stabilized emulsion loading oil-soluble drug of curcumin were investigated in vitro. The results demonstrated that Pickering emulsions released curcumin intestine-specifically (37% in 4 hours with a pH of 6.8), compared with the one in the gastric fluid (3% in 4 hours with a pH of 1.5), proving that MCA had similar pH sensitivity to alginates and probably as the promising candidate in oral drug controllable release.
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