Release Time:2019-03-13  Hits:

Indexed by: Journal Article

Date of Publication: 2019-01-29

Journal: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

Included Journals: SCIE、PubMed

Volume: 15

Page Number: 279-284

ISSN: 1860-5397

Key Words: benzothiazole; benzoxazole; C-H functionalization; mercaptalization; 1,3-propanedithiol

Abstract: A facile and effective C-H functionalization strategy for the synthesis of 2-mercaptobenzothiazoles and 2-mercaptobenzoxazoles is described. 1,3-Propanedithiol was employed to convert benzothiazoles and benzoxazoles to the corresponding heteroarylthiols in the presence of potassium hydroxide and DMSO. This novel protocol is featured by direct C-H mercaptalization of heteroarenes and a simple reaction system.