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Indexed by:期刊论文

Date of Publication:2019-01-29

Journal:BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

Included Journals:PubMed、SCIE

Volume:15

Page Number:279-284

ISSN No.:1860-5397

Key Words:benzothiazole; benzoxazole; C-H functionalization; mercaptalization; 1,3-propanedithiol

Abstract:A facile and effective C-H functionalization strategy for the synthesis of 2-mercaptobenzothiazoles and 2-mercaptobenzoxazoles is described. 1,3-Propanedithiol was employed to convert benzothiazoles and benzoxazoles to the corresponding heteroarylthiols in the presence of potassium hydroxide and DMSO. This novel protocol is featured by direct C-H mercaptalization of heteroarenes and a simple reaction system.