Metal-free C-H mercaptalization of benzothiazoles and benzoxazoles using 1,3-propanedithiol as thiol source
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论文类型：期刊论文
发表时间：2019-01-29
发表刊物：BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
收录刊物：SCIE、PubMed
卷号：15
页面范围：279-284
ISSN号：1860-5397
关键字：benzothiazole; benzoxazole; C-H functionalization; mercaptalization; 1,3-propanedithiol
摘要：A facile and effective C-H functionalization strategy for the synthesis of 2-mercaptobenzothiazoles and 2-mercaptobenzoxazoles is described. 1,3-Propanedithiol was employed to convert benzothiazoles and benzoxazoles to the corresponding heteroarylthiols in the presence of potassium hydroxide and DMSO. This novel protocol is featured by direct C-H mercaptalization of heteroarenes and a simple reaction system.