Release Time:2019-10-22  Hits:

Indexed by: Journal Article

Date of Publication: 2019-04-01

Journal: INORGANIC CHEMISTRY COMMUNICATIONS

Included Journals: SCIE

Volume: 102

Page Number: 51-56

ISSN: 1387-7003

Key Words: Coumarin; Copper(II) ions; Fluorescent sensor; Cell imaging

Abstract: A novel fluorescent sensor CHT based on the excellent optical properties of coumarin derivatives was designed. It was synthesized by Schiff base reaction connected by 7-(N,N-diethylamino) coumarin-3-aldehyde and 2-hydrazinobenzothiazole. The sensor CHT exhibited a significant fluorescence quenching at 540 nm upon the addition of Cu2+ ions. And the sensor exhibited good sensitivity, fast response time, high selectivity for Cu2+ ions in the presence of other important relevant metal ions. In addition, fluorescent sensor CHT was successfully applied for fluorescent imaging of Cu2+ ions in A549 and MCF-7 cells, demonstrating its potential applications in live cell imaging.