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论文类型：期刊论文

发表时间：2018-03-15

发表刊物：JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY

收录刊物：SCIE

卷号：355

期号：,SI

页面范围：67-71

ISSN号：1010-6030

关键字：Fluorescent sensor; Fluorescein derivative; copper(II) ions

摘要：A novel fluorescein-based sensor FR-L was designed and synthesized with good yield for recognizing copper(II) ions in living cells. The sensor, incorporating 5-aminoisophthalic acid methyl ester with fluorescein, was synthesized and fully characterized by crystal test, (HNMR)-H-1, and ESI-MS analyses. The sensor showed a quenching response with the addition of copper(ll) ions which was ascribed to the cooperation between the sensor and copper(II) ions. Meanwhile, the sensor exhibited high selectivity over other metal ions and displayed more obvious changes of absorption. Finally, fluorescent imaging in living cells indicated the capability of detecting copper(II) ions in biological system. (C) 2017 Published by Elsevier B.V.