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Indexed by:期刊论文

Date of Publication:2018-01-01

Journal:Environmental pollution (Barking, Essex : 1987)

Included Journals:PubMed、SCIE

Volume:241

Page Number:19-25

ISSN No.:1873-6424

Key Words:N-EtFOSA; In vivo; In vitro; Earthworm; Bioaccumulation; Biotransformation

Abstract:N-ethyl perfluorooctane sulfonamide (N-EtFOSA) is commonly known as the active ingredient of sulfluramid. It can be degraded to perfluorooctane sulfonic acid (PFOS) in biota and environment. Earthworms (Eisenia fetida) were exposed with N-EtFOSA to examine the bioaccumulation, elimination and metabolism of N-EtFOSA by the earthworms after invivo and invitro exposure. N-EtFOSA could be biodegraded in quartz sands to perfluorooctane sulfonamide (FOSA) and PFOS. In the invivo tests, in addition to parent N-EtFOSA, three metabolites, including perfluorooctane sulfonamide acetate (FOSAA), FOSA and PFOS also accumulated in earthworms as a result of N-EtFOSA biotransformation, with FOSA as the predominant metabolite. The bioaccumulation factor (BAF) and uptake rate coefficient (ku) of N-EtFOSA from sand were 20.4 and 2.41·d-1, respectively. The elimination rate constants (ke) decreased in the order FOSAA (0.130·d-1) > N-EtFOSA (0.118·d-1) > FOSA (0.073·d-1) > PFOS (0.051·d-1). The biotransformation of N-EtFOSA in earthworm was further confirmed by the invitro test involving incubation of earthworm homogenates with N-EtFOSA. This work provides evidence on the accumulation and transformation of N-EtFOSA in terrestrial invertebrates and will be helpful to explore the indirect sources of FOSA and PFOS in environmental biota. Copyright © 2018 Elsevier Ltd. All rights reserved.