Release Time:2019-11-22  Hits:

Indexed by: Journal Papers

Date of Publication: 2019-10-24

Journal: CHEMISTRYSELECT

Included Journals: SCIE

Volume: 4

Issue: 39

Page Number: 11455-11459

ISSN: 2365-6549

Key Words: Sulfobetaine N-chloramines; Chemical synthesis; Antibacterial activity

Abstract: A series of sulfobetaine N-chloramines, covalently combining an N-chloramine unit and a sulfobetaine unit with varied intercharge linkers, were chemically synthesized. Preliminary antibacterial tests showed that the antibacterial activity decreased as the methylene linker increases from -(CH2)(2)- to -(CH2)(8)- except the linker of -(CH2)(6)-, which exerted remarkable bactericidal efficacy unusually. In addition, the analogue with the linker of -(CH2)(10)- displayed the highest bactericidal efficacy among all synthetic N-chloramines, probably due to its neutral zwitterionic characteristic on structure. Our research provided highly efficacious antibacterial agents together with the vital references to design novel ionic N-chloramine biocides.