Release Time:2019-03-13  Hits:

Indexed by: Journal Article

Date of Publication: 2016-10-01

Journal: MOLECULAR IMAGING AND BIOLOGY

Included Journals: Scopus、PubMed、SCIE

Volume: 18

Issue: 5

Page Number: 782-787

ISSN: 1536-1632

Key Words: [F-18] FDS; Biodistribution; Radiation dosimetry; Enterobacteriaceae; PET

Abstract: [F-18]fluorodeoxysorbitol ([F-18]FDS) is the first radiopharmaceutical specific for a category of bacteria and has the potential to specifically detect Enterobacteriaceae infections. The purpose of this study was to testify the safety and investigate the biodistribution and radiation dosimetry of [F-18]FDS in healthy human bodies.
   Six healthy subjects were intravenously injected with 320-520 MBq [F-18]FDS. On each subject, 21 whole-body emission scans and a brain scan were conducted at settled time points within the next 4 h. Residence time for each source organ was determined by multi-exponential regression. Absorbed doses for target organs and effective dose were calculated via OLINDA/EXM.
   No adverse events due to [F-18]FDS injection were observed in the study. The tracer was cleared rapidly from the blood pool through the urinary system. A small portion was cleared into the gut through the hepatobiliary system. The effective dose (ED) was estimated to be 0.021 +/- 0.001 mSv/MBq. The organ receiving the highest absorbed dose was the urinary bladder wall (0.25 +/- 0.03 mSv/MBq).
   [F-18]FDS is safe and well tolerated. The effective dose was comparable to that of other F-18 labeled radiotracers. [F-18]FDS is suitable for human use from a radiation dosimetry perspective.