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论文类型：期刊论文

发表时间：2016-11-01

发表刊物：BIOMEDICAL OPTICS EXPRESS

收录刊物：PubMed、SCIE、EI、Scopus

卷号：7

期号：11

页面范围：4527-4542

ISSN号：2156-7085

关键字：(170.3010) Image reconstruction techniques,(170.3880) Medical and biological imaging,(170.6280) Spectroscopy, fluorescence and luminescence,(170.6960) Tomography

摘要：Dynamic fluorescence molecular tomography (FMT) plays an important role in drug delivery research. However, the majority of current reconstruction methods focus on solving the stationary FMT problems. If the stationary reconstruction methods are applied to the time-varying fluorescence measurements, the reconstructed results may suffer from a high level of artifacts. In addition, based on the stationary methods, only one tomographic image can be obtained after scanning one circle projection data. As a result, the movement of fluorophore in imaged object may not be detected due to the relative long data acquisition time (typically > 1 min). In this paper, we apply extended kalman filter (EKF) technique to solve the non-stationary fluorescence tomography problem. Especially, to improve the EKF reconstruction performance, the generalized inverse of kalman gain is calculated by a second-order iterative method. The numerical simulation, phantom, and in vivo experiments are performed to evaluate the performance of the method. The experimental results indicate that by using the proposed EKF-based second-order iterative (EKF-SOI) method, we cannot only clearly resolve the time-varying distributions of fluorophore within imaged object, but also greatly improve the reconstruction time resolution (similar to 2.5 sec/frame) which makes it possible to detect the movement of fluorophore during the imaging processes. (C) 2016 Optical Society of America