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Indexed by:期刊论文

Date of Publication:2013-08-01

Journal:CHINESE JOURNAL OF CANCER RESEARCH

Included Journals:SCIE、PubMed、ISTIC

Volume:25

Issue:4

Page Number:442-450

ISSN No.:1000-9604

Key Words:Circadian rhythm; breast cancer; circadian proteins; chronotherapy

Abstract:The circadian rhythm is an endogenous time keeping system shared by most organisms. The circadian clock is comprised of both peripheral oscillators in most organ tissues of the body and a central pacemaker located in the suprachiasmatic nucleus (SCN) of the central nervous system. The circadian rhythm is crucial in maintaining the normal physiology of the organism including, but not limited to, cell proliferation, cell cycle progression, and cellular metabolism; whereas disruption of the circadian rhythm is closely related to multi-tumorigenesis. In the past several years, studies from different fields have revealed that the genetic or functional disruption of the molecular circadian rhythm has been found in various cancers, such as breast, prostate, and ovarian. In this review, we will investigate and present an overview of the current research on the influence of circadian rhythm regulating proteins on breast cancer.