Indexed by:期刊论文

Date of Publication:2017-07-01

Journal:Advances in experimental medicine and biology

Included Journals:PubMed

Volume:1038

Page Number:149-171

ISSN No.:0065-2598

Key Words:Drug resistance,Metabolism,Mitochondrial,Signaling pathway

Abstract:Mitochondria are generally considered as a powerhouse in a cell where the majority of the cellular ATP and metabolite productions occur. Metabolic rewiring and reprogramming may be initiated and regulated by mitochondrial enzymes. The hypothesis that cellular metabolic rewiring and reprogramming processes may occur as cellular microenvironment is disturbed, resulting in alteration of cell phenotype, such as cancer cells resistant to therapeutics seems to be now acceptable. Cancer metabolic reprogramming regulated by mitochondrial enzymes is now one of the hallmarks of cancer. This chapter provides an overview of cancer metabolism and summarizes progress made in mitochondria-mediated metabolic regulation in cancer drug resistance.