程昉

个人信息Personal Information

教授

博士生导师

硕士生导师

性别:男

毕业院校:美国华盛顿大学

学位:博士

所在单位:化工学院

学科:药剂学. 药物工程. 精细化工

办公地点:大连理工大学西部校区化工实验楼G309

联系方式:0411-84986336 15941139319

电子邮箱:ffcheng@dlut.edu.cn

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Precise synthesis of discrete and dispersible carbon-protected magnetic nanoparticles for efficient magnetic resonance imaging and photothermal therapy

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论文类型:期刊论文

发表时间:2016-05-01

发表刊物:NANO RESEARCH

收录刊物:EI、SCIE、Scopus

卷号:9

期号:5

页面范围:1460-1469

ISSN号:1998-0124

关键字:magnetic nanoparticles; carbon; Fe3O4; magnetic resonance imaging (MRI); colloidal suspensions; photothermal therapy

摘要:Carbon-protected magnetic nanoparticles exhibit long-term stability in acid or alkaline medium, good biocompatibility, and high saturation magnetization. As a result, they hold great promise for magnetic resonance imaging, photothermal therapy, etc. However, since pyrolysis, which is often required to convert the carbon precursors to carbon, typically leads to coalescence of the nanoparticles, the obtained carbon-protected magnetic nanoparticles are usually sintered as a non-dispersible aggregation. We have successfully synthesized discrete, dispersible, and uniform carbon-protected magnetic nanoparticles via a precise surface/interface nano-engineering approach. Remarkably, the nanoparticles possess excellent water-dispersibility, biocompatibility, a high T (2) relaxivity coefficient (384 mM(-1)center dot s(-1)), and a high photothermal heating effect. Furthermore, they can be used as multifunctional core components suited for future extended investigation in early diagnosis, detection and therapy, catalysis, separation, and magnetism.