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论文类型：期刊论文

发表时间：2020-11-01

发表刊物：JOURNAL OF MEDICAL IMAGING AND HEALTH INFORMATICS

收录刊物：SCIE

卷号：10

期号：11

页面范围：2778-2783

ISSN号：2156-7018

关键字：Breast Cancer Histopathology Image; Convolutional Neural Network; Deep Global Features; Aggregated Descriptors

摘要：Convolutional neural networks (CNNs), successfully used in a great number of medical image analysis applications, have also achieved the state-of-the-art performance in breast cancer histopathology image (BCHI) classification problem recently. However, due to the large varieties among within-class images and insufficient data volume, it is still a challenge to obtain more competitive results by using deep CNN models alone. In this paper, we aim to explore the combination of CNN models with a milestone feature representation method in visual tasks, i.e., vector of locally aggregated descriptors (VLAD), for the BCHI classification, and further propose a novel aggregated deep global feature representation (ADGFR) for this problem. ADGFR adopts the deep features that are extracted from the fully connected layer to form an individual descriptor vector, and augments input images to generate different descriptors for achieving the final aggregated descriptor vector. The individual descriptor vector can effectively keep the global features of benign and malignant image, whose discriminability is further reinforced by the aggregate operation, leading to the more discriminant capability of ADGFR for BCHI. Extensive experiments on the public Break His dataset illuminate that our ADGFR can achieve the optimal classification accuracies of 95.05% at image level and 95.50% at patient level, respectively.