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个人信息Personal Information
副教授
硕士生导师
性别：男
毕业院校：中科院大连化学物理研究所
学位：博士
所在单位：化工学院
学科：药物化学. 药物工程
办公地点：大连理工大学西部校区
联系方式：Office telephone：84986200
电子邮箱：wangss@dlut.edu.cn
Synthesis and in vitro phototoxicity of novel pi-extension derivatives of chlorin e6
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论文类型：期刊论文
发表时间：2017-12-07
发表刊物：NEW JOURNAL OF CHEMISTRY
收录刊物：SCIE
卷号：41
期号：23
页面范围：14279-14287
ISSN号：1144-0546
摘要：Six novel E-32-aryl substituted chlorins (5a-5f) were synthesized via improved regioselective bromination and Suzuki-Miyaura cross-coupling reactions with chlorin e6 (1) as a starting material. All the p-extension photosensitizers 5a-5f exhibited significant bathochromic-shifts (ca. 10 nm) in the far red part of the spectrum called the phototherapeutic window and decreased photobleaching under irradiation of 660 nm light. Moreover, 5a-5f possessed higher phototoxicity in vitro against HepG2 cells (IC50 = 0.73 +/- 0.04, 2.33 +/- 0.22, 0.78 +/- 0.05, 0.50 +/- 0.04, 2.25 +/- 0.16 and 0.65 +/- 0.11 mu M, respectively) compared with chlorin e6 (IC50 = 28.9 +/- 1.2 mu M). The enhanced cellular uptake and reactive oxygen species (ROS) production of modified chlorins were found to be responsible for their increased in vitro phototoxicity.
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