王世盛

个人信息Personal Information

副教授

硕士生导师

性别:男

毕业院校:中科院大连化学物理研究所

学位:博士

所在单位:化工学院

学科:药物化学. 药物工程

办公地点:大连理工大学西部校区

联系方式:Office telephone:84986200

电子邮箱:wangss@dlut.edu.cn

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Biomimetic synthesis of bis-alpha-substituent pyrrolidine alkaloids based on a proposed biosynthetic pathway

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论文类型:期刊论文

发表时间:2016-05-25

发表刊物:TETRAHEDRON LETTERS

收录刊物:SCIE、Scopus

卷号:57

期号:21

页面范围:2219-2221

ISSN号:0040-4039

关键字:Bis-alpha-substituent pyrrolidine alkaloids; Pyrroloxazine alkaloids; Pyrrolozoxazine; Biosynthetic pathway

摘要:A possible biosynthetic pathway of bis-alpha-substituent pyrrolidine alkaloids was proposed. Based on the proposed biosynthetic pathway, six pyrrolozoxazine alkaloids and one N-alkyl-5-hydroxymethyl-pyr-role-2-carbaldehyde alkaloid were synthesized. In a mixture of acetic acid and triethylamine, condensation of n-fructose and D-amino acids produced pyrrolozoxazine alkaloids. Replacing D-amino acids with tyramine can afford pyrrolezanthine a N-alkyl-5-hydroxymethyl-pyr-role-2-carbaldehyde alkaloid. (C) 2016 Published by Elsevier Ltd.