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论文类型：期刊论文

发表时间：2016-02-01

发表刊物：ONCOLOGY REPORTS

收录刊物：SCIE、PubMed、Scopus

卷号：35

期号：2

页面范围：1101-1108

ISSN号：1021-335X

关键字：SZC017; oleanolic acid derivative; MGC-803; SGC-7901; apoptosis

摘要：Oleanolic acid (OA) and its several derivatives possess chemopreventive and chemotherapeutic functions against a series of cancer types. Many chemotherapeutic compounds are effective in improving the quality of life and prolonging the survival of patients with gastric cancer, therefore progress in the treatment of gastric cancer, especially the anticancer effects of OA derivatives must be achieved. The inhibitory effect of SZC017, a newly synthesized derivative of OA, on cell viability was determined by MTT assay. Furthermore, flow cytometry, transmission electron microscopy, and western blot analysis revealed that the inhibition of cell viability by OA was mediated by triggering the intrinsic apoptosis of gastric cancer cells, and inducing S phase arrest of SGC7901 cells. Mechanistically, SZC017 was effective against gastric cancer cells via inhibiting Akt/NF-kappa B signaling and topoisomerase I and Ha proteins. Taken together, our data indicate that SZC017 may be a potential chemotherapeutic agent against gastric cancer cells.