|
个人信息Personal Information
副教授
硕士生导师
性别：男
毕业院校：中科院大连化学物理研究所
学位：博士
所在单位：化工学院
学科：药物化学. 药物工程
办公地点：大连理工大学西部校区
联系方式：Office telephone：84986200
电子邮箱：wangss@dlut.edu.cn
Tumor Acidic Microenvironment Targeted Pyropheophorbide a Dimer, an Alternative Strategy for Simultaneous Tumor Fluorescence Imaging and PDT Treatment
点击次数：
论文类型：期刊论文
发表时间：2019-01-01
发表刊物：MACROHETEROCYCLES
收录刊物：SCIE
卷号：12
期号：2
页面范围：187-192
ISSN号：1998-9539
关键字：Pyropheophorbide a; dimer; FRET; cis-aconitic anhydride; phototoxicity; PDT
摘要：Targeting tumor acidic microenvironment, a cis-aconitate linked pyropheophorbide a dimer 3 was designed and prepared The observed fluorescence quenching of 3 verified our FRET based molecular design. Acid-dependent cleavage in aqueous solution, singlet oxygen generation, and cytotoxiciry against HepG2 cell lines of dimer 3 were investigated. The dimer demonstrated different levels of fluorescence recovery when incubated in acidic aqueous environment as well as effective phototoxicity against HepG2 cells.
上一条：Screening and identification of natural ligands of tyrosinase from Pueraria lobata Ohwi by a combination of ultrafiltration and LC-MS.
下一条：Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor B and STAT3 in vitro and in vivo