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个人信息Personal Information
副教授
硕士生导师
性别：男
毕业院校：中科院大连化学物理研究所
学位：博士
所在单位：化工学院
学科：药物化学. 药物工程
办公地点：大连理工大学西部校区
联系方式：Office telephone：84986200
电子邮箱：wangss@dlut.edu.cn
环巴胺类似物的合成及体外抗肿瘤细胞活性研究
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论文类型：期刊论文
发表时间：2022-07-03
发表刊物：天然产物研究与开发
卷号：27
期号：5
页面范围：890-895
ISSN号：1001-6880
摘要：Cyclopamine is a steroid alkaloid with Hedgehog signal pathway
inhibitory activity and exhibits significant antitumoractivity. In this
study, cyclopamine analogues were synthesized by reduction, oxidation
and methylation from an available alkaloid, jervine. The structures of
the yielded compounds were determined by MS,1 D and 2D NMR. Structures
of compounds 4,9 and 10 have not been reported previously. The antitumor
activities of the 10 synthesized compounds against Aspc-1 and SGC-7901
cancer cells were evaluated by MTT method.
备注：新增回溯数据