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发表时间：2012-01-01

发表刊物：大连理工大学学报

所属单位：实验室与设备管理处

卷号：52

期号：2

页面范围：162-166

ISSN号：1000-8608

摘要：The aim of this research is to develop a rapid,accurate and no sample
   preparation required method to identify 8 kinds of oral hypoglycemic
   active pharmaceutical ingredient(API)(solid and liquid) by using near
   infrared(NIR) spectroscopy.64 NIR spectra are utilized to establish the
   calibration model and rest 32 spectra are utilized to validate the
   performance of the model.On the original data,the first derivative
   combined with scaling to the first range method is conducted as the
   optimum pre-processing method at 12 072.3-4 000.0 cm~(-1),and 8 oral
   hypoglycemic APIs can be well identified by this model.With this
   approach,no error determinations are assigned to a wrong class,which
   indicates that the NIR method is appropriate for fast identification of
   oral hypoglycemic APIs in the inspection and acceptance before
   manufacture and warehousing of drug products in the pharmaceutical
   industry.

备注：新增回溯数据