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论文类型：期刊论文

发表时间：2014-08-01

发表刊物：PLANTA MEDICA

收录刊物：SCIE、PubMed、Scopus

卷号：80

期号：13

页面范围：1124-1130

ISSN号：0032-0943

关键字：Scopolia tangutica; Solanaceae; alkaloid; hydroxycinnamic acid amide; mu-opioid receptor

摘要：Four new hydroxycinnamic acid amides, scotanamines A-D (1-4), and seven known alkaloids, including N-1,N-10-di-dihydrocaffeoylspermidine (5), scopolamine (6), anisodamine (7), hyoscyamine (8), anisodine (9), caffeoylputrescine (10), and N-1-caffeoyl-N-3-dihydrocaffeoylspermidine (11), were obtained from the roots of Scopolia tangutica. The present study represents the first recognition of hydroxycinnamic acid amides containing putrescine or spermidine in S. tangutica. Compound 1, in particular, contains a moiety resulting from the condensation of nortropinone and putrescine. Compound 2 exhibited moderate agonist activity at the mu-opioid receptor (EC50 = 7.3 mu M). Compound 2 was tested in vivo and induced analgesia in mice. The analgesic effect was recorded using the tail-flick assay and was reversed by naloxone.