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论文类型：期刊论文

发表时间：2013-07-01

发表刊物：CHINESE CHEMICAL LETTERS

收录刊物：SCIE、ISTIC

卷号：24

期号：7

页面范围：617-618

ISSN号：1001-8417

关键字：2 beta,3 alpha-Dihydroxyurs-12-en-28-oic acid; Ursolic acid; Glycogen phosphorylase; Corosolic acid

摘要：2 beta,3 alpha-Dihydroxyurs-12-en-28-oic acid (6) is a naturally occurring diastereoisomer of corosolic acid with glycogen phosphorylase inhibitory activity. A new strategy for the semi-synthesis of 6 was developed. Using the commercially available ursolic acid (1) as the starting materials, 6 was synthesized through five facile reactions with a high stereoselectivity and an overall yield of 47.3%. The structure of 6 was confirmed by optical rotation, ESI-MS, H-1 NMR and C-13 NMR data. (C) 2013 Shi-Sheng Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.