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发表时间：2011-01-01

发表刊物：功能材料

卷号：42

期号：9

页面范围：1690

ISSN号：1001-9731

摘要：3-D porous scaffolds has an important role in tissue
   engineering.Supercritical CO_2(ScCO_2)induced phase separation method
   was employed to produce porous poly caprolactone(PCL)3-D scaffold,and
   the effects of process parameters on pore size and structure were also
   investigated.A self-designed experiment system was set up.Four solution
   concentrations(15%,20%,25%and 30wt%),three CO_2pressures(10,12and
   14MPa),and three temperatures(35,40and 45℃)were examined using the
   system.The morphologies of the scaffolds were examined by scanning
   electronic microscope.Pore distribution and pore size of the scaffolds
   were measured using image-pro-polus software.Porous PCL 3-D scaffolds
   with pore size range of 40-80mum were obtained.The results indicated
   that the pore size decreased as the solution concentration
   increased;while it also decreased as the temperature
   decreased.However,the change of CO_2pressure had no significant effect
   on pore size.The results were also explained qualitatively in terms of
   the thermodynamics calculations using ScCO_2-AC-PCL ternary system.

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