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论文类型：会议论文

发表时间：2017-04-27

收录刊物：EI

页面范围：198-206

摘要：Parkinson's disease (PD) is a chronic disease that develops over years and varies dramatically in its clinical manifestations. A preferred strategy to resolve this heterogeneity and thus enable better prognosis and targeted therapies is to segment out more homogeneous patient sub-populations. However, it is challenging to evaluate the clinical similarities among patients because of the longitudinality and temporality of their records. To address this issue, we propose a deep model that directly learns patient similarity from longitudinal and multi-modal patient records with an Recurrent Neural Network (RNN) architecture, which learns the similarity between two longitudinal patient record sequences through dynamically matching temporal patterns in patient sequences. Evaluations on real world patient records demonstrate the promising utility and efficacy of the proposed architecture in personalized predictions. Copyright © by SIAM.