Release Time:2019-03-11  Hits:

Indexed by: Journal Article

Date of Publication: 2018-03-21

Journal: CHEMCATCHEM

Included Journals: EI、SCIE

Volume: 10

Issue: 6

Page Number: 1248-1252

ISSN: 1867-3880

Key Words: asymmetric catalysis; heterocycles; heterogeneous catalysis; nanostructures; supported catalysts

Abstract: Porous carbon nanosheets (PCNs) were used for the first time as a support to immobilize a quinine-squaramide catalyst for the asymmetric Friedel-Crafts addition of pyrazolones to isatin ketimines. Relying on its open structure with a macroporous network as well as hydrophobicity, the PCN-supported catalyst presented catalytic performance comparable to its homogeneous catalyst; the products were obtained in high yields (up to 90%) with high ee values (up to 99%). Recycling batch reactions together with a continuous flow process confirmed the stability of the catalyst.