柏雪梅, Email: xbai@dlut.edu.cn

  医学博士，博士后，大连理工大学基础医学院副教授，博士生导师。兼任山东省免疫学会青年工作委员会委员。长期从事病毒感染与固有免疫调控的基础及应用研究。相关成果以第一作者、共同第一作者和共同作者身份发表在Nature Communications、Cell Death Differ、Adv Sci、PNAS等国际顶级及权威免疫学期刊。以项目负责人身份主持国家自然科学基金青年项目，中国博士后基金面上项目，山东省博士后创新项目，参与多项国家自然科学基金面上项目。

欢迎对免疫学，病原感染，炎症性疾病等方向感兴趣的本科生、硕士生、博士生及博士后加入我们团队。

主持或参加的国家自然科学基金项目/课题：

(1) 国家自然科学基金委员会，青年科学基金项目，82301984，PRMT9在巨噬细胞极化中的作用及其机制研究，2024-01-01至2026-12-31，30万元，在研，主持。

(2) 国家自然科学基金委员会，面上项目，82072535，基于小胶质细胞OPN/CTSB/NLRP3轴介导的炎症反应探讨H2S促进缺氧缺血性脑损伤后神经功能重建的机制研究，2021-01-01 至2024-12-31，55万元，在研，参与。

(3) 国家自然科学基金委员会，面上项目，81873768，H2S调控BMSCs外泌体相关miR-9/TN-C轴对HIBD后的神经保护作用及机制研究，2019-01-01至2022-12-31, 56万元, 结题, 参与。

(4) 国家自然科学基金委员会，面上项目，31871160，缩宫素对肠道黏膜固有层巨噬细胞极化的调节及其在IBD发生发展中的作用，2019-01-01至2022-12-31， 60万元，结题，参与。

主持或参加的其他科研项目/课题（国家自然科学基金项目除外）：

(1) 中国博士后科学基金第75批面上资助，2024M751821，PRMT9通过调控STAT1甲基化修饰控制巨噬细胞极化的机制研究，2025-01-01至2027-12-31，8万，结题，主持

(2) 山东省博士后创新项目，SDCX-ZG-202400006 PRMT9通过调控STAT1甲基化修饰控制巨噬细胞极化的机制研究，2024-07至2026-06，5万，主持

(3) 山东省优秀青年基金，天然免疫抗病毒信号转导调控机制研究，2022-01-01至2024-12-31，ZR2021YQ48，40万，在研，参与

代表性论著（第一作者）

(1) Bai Xuemei^#, Dong N, Cao N, Zhou M, Yuan J, Zhang Y, Liu Y, Zhang J, Chen T, Liu F, Sun W, Zheng Y, Zhao W, Shu Q, Gao C, Liu B. ZNF593 regulates the cGAS-mediated innate immune response by attenuating cGAS-DNA binding. Cell Death Differ. 2025 Apr 10.

(2) Bai Xuemei^#, Sui C, Liu F, Chen T, Zhang L, Zheng Y, Liu B, Gao C. The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation., Nature Communications, 2022, 13(1): 5016-5016  

(3) Yin Sen^#; Bai Xuemei^#; Xin Danqing; Li Tingting; Chu Xili; Ke Hongfei; Han Min; Chen Wenqiang; Li Xingang; Wang Zhen ; Neuroprotective Effects of the Sonic Hedgehog Signaling Pathway in Ischemic Injury through Promotion of Synaptic and Neuronal Health, Neural Plasticity, 2020, 2020: 8815195

(4) Dexiang Liu^#; Xuemei Bai^#; Weiwei Ma; Danqing Xin; Xili Chu; Hongtao Yuan; Jie Qiu; HongFei Ke; Sen Yin; Wenqiang Chen; Zhen Wang ; Purmorphamine Attenuates Neuro Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling, Frontiers in Pharmacology, 2020, 11: 204

(5) Xuemei Bai^#; Song Liu; Lin Yuan; Yunkai Xie; Tong Li; Lingxiao Wang; Xueer Wang; Tiantian Zhang; Shucun Qin; Guohau Song; Li Ge; Zhen Wang ; Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice, Brain Research, 2016, 1646: 410-417

共同作者

(1) Qin F, Cao R, Bai Xuemei, Yuan J, Sun W, Zheng Y, Qi X, Zhao W, Liu B, Gao C. Listerin Alleviates Alzheimer's Disease through IRE1-mediated Decay of TLR4 mRNA. Adv Sci (Weinh). 2025 May 31:e14956. 

(2) Qin F, Cao R, Cui W, Bai Xuemei, Yuan J, Zhang Y, Liu Y, Cao N, Dong N, Zhou M, Chen T, Liu F, Sun W, Zheng Y, Zhao W, Liu B, Gao C. Listerin promotes α-synuclein degradation to alleviate Parkinson's disease through the ESCRT pathway. Sci Adv. 2025 Feb 14;11(7):eadp3672.

(3) Yaxing Liu, Jiahua Yuan, Yuling Zhang, Fei Qin, Xuemei Bai, Wanwei Sun, Tian Chen, Feng Liu, Yi Zheng, Xiaopeng Qi, Wei Zhao, Bingyu Liu & Chengjiang Gao. OTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation. Cell Death Differ. 2024 Jun;31(6):753-767.

(4) Fei Qin; Baoshan Cai; Runyu Cao; Xuemei Bai; Jiahua Yuan; Yuling Zhang; Yaxing Liu; Tian Chen; Feng Liu; Wanwei Sun; Yi Zheng; Xiaopeng Qi; Wei Zhao; Bingyu Liu; Chengjiang Gao; Listerin promotes cGAS protein degradation through the ESCRT pathway to negatively regulate cGAS- mediated immune response, PNAs, 2023, 120(52): e2308853120

(5) Danqing Xin, Tingting Li, Xili Chu, Hongfei Ke, Zhuoya Yu, Lili Cao, Xuemei Bai, Dexiang Liu, Zhen Wang. Mesenchymal stromal cell-derived extracellular vesicles modulate microglia/macrophage polarization and protect the brain against hypoxia-ischemic injury in neonatal mice by targeting delivery of miR-21a-5p. Acta Biomater. 2020 Sep 1;113:597-613.

(6) Chunlei Yang, Tong Li, Hao Xue, Lingxiao Wang, Lin Deng, Yunkai Xie, Xuemei Bai,Danqing Xin, Hongtao Yuan, Jie Qiu, Zhen Wang, Gang Li. Inhibition of Necroptosis Rescues SAH-Induced Synaptic Impairments in Hippocampus via CREB-BDNF Pathway. Front Neurosci. 2019 Jan 7;12:990.

(7) Xin Zhou, Xili Chu, Danqing Xin, Tingting Li, Xuemei Bai, Jie Qiu, Hongtao Yuan, Dexiang Liu, Dachuan Wang, Zhen Wang. L-Cysteine-Derived H2S Promotes Microglia M2 Polarization via Activation of the AMPK Pathway in Hypoxia-Ischemic Neonatal Mice. Front Mol Neurosci. 2019 Mar 11;12:58.

(8) Danqing Xin, Xili Chu, Xuemei Bai, Weiwei Ma, Hongtao Yuan, Jie Qiu, Changxing Liu, Tong Li, Xin Zhou, Wenqiang Chen, Dexiang Liu, Zhen Wang. l-Cysteine suppresses hypoxia-ischemia injury in neonatal mice by reducing glial activation, promoting autophagic flux and mediating synaptic modification via H2S formation. Brain Behav Immun. 2018 Oct;73:222-234.

(9) Tong Li, Lingxiao Wang, Quan Hu, Song Liu, Xuemei Bai, Yunkai Xie, Tiantian Zhang, Shishi Bo, Xiangqian Gao, Shuhua Wu, Gang Li, Zhen Wang. Neuroprotective Roles of lCysteine in Attenuating Early Brain Injury and Improving Synaptic Density via the CBS/H2S Pathway Following Subarachnoid Hemorrhage in Rats. Front Neurol. 2017 May 2;8:176.

(10) Quan Hu, Tong Li, Lingxiao Wang, Yunkai Xie, Song Liu, Xuemei Bai, Tiantian Zhang, Shishi Bo, Danqing Xin, Hao Xue, Gang Li, Zhen Wang. Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats. Front Cell Neurosci. 2017 Jan 18;10:306.

(11) Song Liu, Danqing Xin, Lingxiao Wang, Tiantian Zhang, Xuemei Bai, Tong Li, Yunkai Xie, Hao Xue, Shishi Bo, Dexiang Liu, Zhen Wang. Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H2S system: Role of oxidative stress and endoplasmic reticulum stress. Redox Biol. 2017 Oct;13:528-540.

(12) Lin Yuan, Song Liu, Xuemei Bai, Yan Gao, Guangheng Liu, Xueer Wang, Dexiang Liu, Tong Li, Aijun Hao, Zhen Wang. Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice. J Neuroinflammation. 2016 Apr 13;13(1):77.