曹建芳

2014年毕业于大连理工大学精细化工国家重点实验，师从彭孝军院士

2014年-2020年 辽宁工业大学化工学院，副教授，硕士生导师

2020-至今 大连理工大学盘锦校区化工系，副教授，硕士生导师

主要研究方向包括：

（1）  光功能材料的发光机理与分子设计

（2）  荧光探针识别机制的理论研究

已发表论文：

 

(1) Jianfang Cao*, Xue Ma, Xinyu Chen, Tianci Zhang, Wen Sun*,  Theoretical perspective on fine-tuning ISC efficiency in D-A BODIPY photosensitizers through heteroatom incorporation and nitrogen ring strain modulation, Chinese Chemical Letters, 2025, 110897

(2) Jianfang Cao, Tianci Zhang, Xinyu Chen, Xue Ma, Jiangli Fan*, The controllable of BODIPY dimers without installing blocking groups as both fluorescence and singlet oxygen generators, Smart Molecules, 2024, e20240023

(3) Jianfang Cao*, Xinyu Chen, Xue Ma, Tianci Zhang, Wen Sun*, Theoretical study on thephotophysical properties of thiophene-fused-type BODIPY series molecules in fluorescence imaging and photodynamic therapy, Physical Chemistry Chemical Physics, 2024, 26(32): 21520-21529

(4) Wenkai Liu, Shan He, Xue Ma, Chengyuan Lv, Hua Gu, Jianfang Cao, Jianjun Du, Wen Sun, Jiangli Fan, Xiaojun Peng, Frontispiz: Near–Infrared Heptamethine Cyanine Photosensitizers with Efficient Singlet Oxygen Generation for Anticancer Photodynamic Therapy, Angewandte Chemie, 2024, 63(47): e202411802

(5) Jianfang Cao*, Tianci Zhang, Wen Sun*, The control of chemical structures of dual-functioning photosensitizers as both therapeutic and imaging agents. Dyes and Pigments, 2022, 208, 110797.

(6) Jianfang Cao, Wen Sun，Jiangli Fan*, Insights into bishemicyanines with long emission wavelengths and high sensitivity in viscous environments. Chinese Chemical Letters., 2020, 31, 1402–1405.

(7) He Ma, Yang Lu, Zhibin Huang, Saran Long, Jianfang Cao, Zhen Zhang, Xiao Zhou, Chao Shi, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng*, ER-Targeting Cyanine Dye as an NIR Photoinducer to Efficiently Trigger Photoimmunogenic Cancer Cell Death. Journal of the American Chemical Society, 2022, 144 (8), 3477-3486.

(8) Xiaojing Li, Mingwang Yang, Jianfang Cao, Hua Gu, Weijian Liu, Tianping Xia, Wen Sun*, Jiangli Fan*, Xiaojun Peng, H-Aggregates of Prodrug-HemicyanineConjugate for Enhanced PhotothermalTherapy and Sequential Hypoxia-ActivatedChemotherapy. Acs Materials Letters, 2022, 4 (4), 724-732.

(9) He Ma, Saran Long*, Jianfang Cao, Feng Xu, Panwang Zhou, Guang Zeng, Xiao Zhou, Chao Shi, Wen Sun, Jianjun Du, Keli Han, Jiangli Fan, Xiaojun Peng, New Cy5 photosensitizers for cancer phototherapy: a low singlet-triplet gap provides high quantum yield of singlet oxygen. Chemical Science, 2021, 12 (41), 13809-13816.

(10) Hua Gu, Weijian Liu, Shijie Zhen, Saran Long, Wen Sun, Jianfang Cao, Xueze Zhao, Jianjun Du, Jiangli Fan*, Xiaojun Peng, “Internal and External Combined” Nonradiative Decay-Based Nanoagents for Photoacoustic Image-Guided Highly Efficient Photothermal Therapy. ACS Applied Materials & Interfaces, 2021, 13 (39), 46353-46360.

(11) Miao Li, Wen Sun, Ruisong Tian, Jianfang Cao, Ye Tian, Bhaskar Gurram, Jiangli Fan, Xiaojun Peng*, Smart J-aggregate of cyanine photosensitizer with the ability to target tumor and enhance photodynamic therapy efficacy. Biomaterials, 2021, 269, 120532.

(12) Dongmei Xi, Ming Xiao, Jianfang Cao, Luyang Zhao, Ning Xu, Saran Long, Jiangli Fan, Kun Shao, Wen Sun,* Xuehai Yan, and Xiaojun Peng*.NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy. Adv. Mater. 2020, 32, 1907855.

(13) Xueze Zhao, Saran Long, Mingle Li, Jianfang Cao, Yachen Li, Lianying Guo,Wen Sun, Jianjun Du, Jiangli Fan*, and Xiaojun Peng. Oxygen-Dependent Regulation of Excited-State Deactivation Process of Rational Photosensitizer for Smart Phototherapy. J. Am. Chem. Soc. 2020, 142, 1510−1517.

(14) Yahui Chen, Yu Fang, Hao Gu, Jian Qiang, Haidong Li, Jiangli Fan, Jianfang Cao, Fang Wang, Sheng Lu*, Xiaoqian Chen*, Color-Tunable and ESIPT-Inspired Solid Fluorophores Based on Benzothiazole Derivatives: Aggregation-Induced Emission, Strong Solvatochromic Effect, and White Light Emission. ACS Applied Materials & Interfaces, 2020, 12 (49), 55094-55106.

(15) Zhen Zhang, Saran Long, Jianfang Cao, Jianjun Du, Jiangli Fan*, and Xiaojun Peng, Revealing the Photodynamic Stress In Situ with a Dual-Mode Two-Photon 1O2 Fluorescent Probe. ACS Sensors, 2020, 5 (5), 1411-1418.

(16) Fengli Gao, Liuju Li, Jiangli Fan,* Jianfang Cao, Yueqing Li, Liangyi Chen,and Xiaojun Peng . An Off−On Two-Photon Carbazole-Based Fluorescent Probe: Highly Targeting and Super-Resolution Imaging of mtDNA. Analytical Chemistry, 2019, 91(5), 3336-3341.

(17) Ming Xiao, Wen Sun , Jiangli Fan^*, Jianfang Cao, Yueqing Li,  Kun Shao, Miao Li, Xiaojing Li, Yao Kang, Wendi Zhang, Saran Long, Jianjun Du, Xiaojun Peng, Aminopeptidase-N-activated theranostic prodrug for NIR tracking of local tumor chemotherapy. Adv. Funct. Mater. 2018, 1805128.

(18) Miao Li, Jiangli Fan, Jianjun Du, Jianfang Cao, Xiaojun Peng*, Inhibiting proton interference in PET chemosensors by tuning the HOMO energy of fluorophores. Sensors Actuators B: Chem. 2018, 259, 626-632.

(19) Hao Zhu, Jiangli Fan*, Miao Li, Jianfang Cao, Jingyun Wang, Xiaojun Peng*.A "Distorted-BODIPY"-based fluorescent probe for imaging of cellular viscosity in live cells. Chemistry – A European Journal, 2014, 20(16), 4691-4696

(20) Jianfang Cao, Jiangli Fan, Wen Sun, Zhigang Yang, Chong H, Xiaojun Peng*, The ratiometric dual-fluorescence of near infrared absorbing aminocyanine dyes: A mechanistic study. Dyes and Pigments, 2017, 141:379-387.

(21) Jianfang Cao, Jiangli Fan, Wen Sun, Yu Guo, Hongmei Wu and Xiaojun Peng*, The photoprocess effects of an amino group located at different positions along the polymethine chain in indodicarbocyanine dyes. RSC Adv., 2017, 7: 30740-30746.

(22) 曹建芳*, 樊江莉*, 郭宇, 吴红梅. 密度泛函方法研究噻唑橙类菁染料的光谱性质. 应用化学, 2017, 12(34):1474-1480.

(23) Jianfang Cao*, Hongmei Wu, Yue Zheng, Fangyuan Nie, Ming Li, and Chenchen Zou, Hydrogen-bonding study of photoexcited 4-nitro-1,8-naphthalimide in hydrogen-donating solvents. Open Phys. 2016; 14:621–627.

(24) Jianfang Cao, Chong Hu, Wen Sun, Qunli Xu, Jiangli Fan, Fengling Song, Shiguo Sun, Xiaojun Peng^*, The mechanism of different sensitivity of meso-substituted and unsubstituted cyanine dyes in rotation-restricted environments for biomedical imaging applications. Rsc Advances, 2014, 4(26):13385-13394. 

(25) Zhigang Yang, Jianfang Cao, Yanxia He, Jung Ho Yang, Taeyoung Kim, Xiaojun Peng^*, Jong Seung Kim, Macro-/micro-environment-sensitive chemosensing and biological imaging. Chem. Soc. Rev., 2014, 43(13): 4563-4601.

(26) Hao Zhu, Jiangli Fan^*, Miao Li, Jianfang Cao, Jingyun Wang, Xiaojun Peng^*, A "Distorted-BODIPY"-based fluorescent probe for imaging of cellular viscosity in live cells. Chem-eur J, 2014, 20(16): 4691-4696.

(27) Guanghui Cheng, Jiangli Fan^*, Wen Sun, Jianfang Cao, Xiaojun Peng^*, A near-infrared fluorescent probe for selective detection of HClO based on Se-sensitized aggregation of heptamethine cyanine dye. Chem. Commun., 2014, 50(8):1018-1020.

(28) Jianfang Cao, Chong Hu, Fei Liu, Wen Sun, Jiangli Fan, Fengling Song, Shiguo Sun, Xiaojun Peng^*, Mechanism and nature of the different viscosity sensitivities of hemicyanine dyes with various heterocycles. Chemphyschem, 2013, 14(8): 1601 -1608.

(29) Jianfang Cao^*, Tong Wu, Wen Sun, Chong Hu, Time-dependent density functional theory study on the excited-state hydrogen bonding strengthening of photoexcited 4-amino-1,8-naphthalimide in hydrogen-donating solvents. J. Phys. Org. Chem., 2013, 26(4): 289-294.

(30)  Honglin Li^#, Jianfang Cao^#, Hao Zhu, Jiangli Fan^*, Xiaojun Peng^*, Optical Pd²⁺ sensing by rhodamine hydrazone ligands: different stoichiometries in aqueous/nonaqueous environments, Tetrahedron Lett., 2013, 54(33):4357-4361.（共同第一作者）

(31) Chong Hu, Wen Sun, Jianfang Cao, Pan Gao, Jingyun Wang, Jiangli Fan, Fengling Song, Shiguo Sun, Xiaojun Peng^*, A ratiometric near-Infrared fluorescent probe for hydrazine and its in vivo applications. Org. Lett., 2013, 15(15): 4022-4025.

(32) Fei Liu, Tong Wu, Jianfang Cao, Hua Zhang, Mingming Hu, Shiguo Sun, Fengling Song, Jiangli Fan, Jingyun Wang^*, Xiaojun Peng^*, A novel fluorescent sensor for detection of highly reactive oxygen species, and for imaging such endogenous hROS in the mitochondria of living cells. Analyst, 2013, 138(3): 775 - 778.

(33) Fei Liu, Tong Wu, Jianfang Cao, Shuang Cui, Zhigang Yang, Shiguo Sun, Fengling Song, Jiangli Fan, Jingyun Wang, Xiaojun Peng^*, Ratiometric detection of viscosity using a two-photon fluorescent sensor. Chem-eur J, 2013, 19(5):1548-1553.

(34) Wen Sun, Jiangli Fan^*, Chong Hu, Jianfang Cao, Hua Zhang, Xiaoqing Xiong, Jingyun Wang, Shuang Cui, Shiguo Sun, Xiaojun Peng^*,  A two-photon fluorescent probe with near-infrared emission for hydrogen sulfide imaging in biosystems, Chem. Commun. 2013, 49(37): 3890-3892.

(35) Hao Zhu , Jiangli Fan^*, Shiling Zhang, Jianfang Cao, Kedong Song, Dan Ge, Huijuan Dong, Jingyun Wang,  Xiaojun Peng^*, Ratiometric fluorescence imaging of lysosomal Zn²⁺ release under oxidative stress in neural stem cells, Biomaterials Science, 2013, 2(1):89-97.

(36) Na Jiang, Jiangli Fan^*, Tao Liu, Jianfang Cao, Bo Qiao, Jingyun Wang, Pan Gao, Xiaojun Peng^*, A near-infrared dye based on BODIPY for tracking morphology changes in mitochondria. Chem. Commun., 2013, 49(30): 10620 -10622.

(37) Hua Zhang, Jiangli Fan^*, Jingyun Wang, Bairui Dou, Fan Zhou, Jianfang Cao, Junle Qu, Zhi Cao, Weijie Zhao, Xiaojun Peng^*, Ratiometric fluorescence imaging of lysosomal Zn²⁺ release under oxidative stress in neural stem cells. J. Am. Chem. Soc., 2013, 135(46):17469-17475.

(38)  Zhigang Yang, Yanxia He, Jae-Hong Lee, Nayoung Park, Myungkoo Suh, Weon-Sik Chae, Jianfang Cao, Xiaojun Peng, Hyosung Jung, Chulhun Kang^*, Jong Seung Kim^*, A self-calibrating bipartite viscosity sensor for mitochondria. J. Am. Chem. Soc., 2013, 135(24):9181-9185.

(39)  Jianfang Cao, Tong Wu, Chong Hu, Tao Liu, Wen Sun, Jiangli Fan, Xiaojun Peng^*, The nature of the different environmental sensitivity of symmetrical and unsymmetrical cyanine dyes: an experimental and theoretical study. Phys. Chem. Chem. Phys., 2012, 14(39):13702-13708.

 

研究项目

（1）横向 合同编号HX20231330，光动力治疗和成像双功能光敏剂的开发, 曹建芳，2023-2025年，14万元，主持，在研

（2）大 连 理 工 大 学基本科研业务费，DUT20RC(3)076  双半菁染料产生比例双荧光的机理研究，35万元，主持，已结题。

（3）2020年辽宁省自然科学基金面上项目，2020-MS-293, 吩噻嗪类荧光染料作为焦磷酸盐探针的设计及应用，5万元，主持，已结题。

（4）国家自然科学青年科学基金项目，21606118，近红外氨基菁染料产生比例双荧光的机理研究，20万元，主持，已结题。

（5）大连理工大学精细化工国家重点实验开放基金项目，KF1614，近红外双荧光粘度探针的分子设计及机理研究，5万元，主持，已结题。

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