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论文类型：期刊论文

发表时间：2013-09-16

发表刊物：MATERIALS CHEMISTRY AND PHYSICS

收录刊物：SCIE、EI、Scopus

卷号：141

期号：2-3

页面范围：997-1004

ISSN号：0254-0584

关键字：Magnetic materials; Biomaterials; Nanostructures; Magnetic properties

摘要：It is significant interest in developing novel multifunctional nanocarrier with complementary roles in recent years. Magnetic Fe3O4/graphene oxide (GO) nanocomposites with integrated characteristics of magnetic resonance imaging (MRI) and controlled drug delivery were prepared by an inverse co-precipitation method. The microstructure and physical properties of Fe3O4/GO nanocomposites were investigated by transmission electron microscope, wide-angle X-ray diffraction, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, thermogravimetric analyzer and superconducting quantum interference device magnetometer. The obtained nanocomposites exhibited superparamagnetic property with the saturation magnetization of 63.3 Am-2 kg(-1) at room temperature. In vitro MRI experiments revealed that Fe3O4/GO nanocomposites possessed an excellent MRI enhancement effect. 5-Fluorouracil (5-FU) as an anti-tumor model drug was loaded onto the surface of Fe3O4/GO nanocomposites. The drug loading capacity of this nanocarrier was as high as 0.37 mg mg(-1) and the drug release behavior showed pH-dependence. The results suggested that the as-prepared Fe3O4/GO nanocomposites showed great potential as an effective multifunctional nanoplatform for MRI and controlled drug delivery. Crown Copyright (c) 2013 Published by Elsevier B.V. All rights reserved.