Release Time:2019-03-13  Hits:

Indexed by: Journal Article

Date of Publication: 2016-02-01

Journal: CHEMICAL RECORD

Included Journals: PubMed、SCIE

Volume: 16

Issue: 1

Page Number: 84-97

ISSN: 1527-8999

Key Words: biaryls; cross-coupling; homogeneous catalysis; palladium; Suzuki-Miyaura reaction

Abstract: As one of the most powerful and versatile methods for the construction of carbon-carbon bonds, the Suzuki-Miyaura cross-coupling reaction has attracted great attention over the past three decades. In recent years, a huge amount of interest has been focused on the development of ligand-free Suzuki-Miyaura reaction systems, which have the advantages of low cost, mild reaction conditions, and easy operation. So far, a number of ligand-free Suzuki-Miyaura reaction systems have been developed by using simple palladium salts, nanopalladium, or supported palladium catalysts. In this account, we will review our recent research on the oxygen-promoted ligand-free Suzuki-Miyaura reaction. Interestingly, the oxygen-promoting effect has been observed in different reaction media, including polyethylene glycol, organic/water mixed solvents and pure water. The oxygen-promoted reaction systems demonstrate high efficiency for the construction of biaryls.