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Indexed by:期刊论文

Date of Publication:2016-02-01

Journal:CHEMICAL RECORD

Included Journals:SCIE、PubMed

Volume:16

Issue:1

Page Number:84-97

ISSN No.:1527-8999

Key Words:biaryls; cross-coupling; homogeneous catalysis; palladium; Suzuki-Miyaura reaction

Abstract:As one of the most powerful and versatile methods for the construction of carbon-carbon bonds, the Suzuki-Miyaura cross-coupling reaction has attracted great attention over the past three decades. In recent years, a huge amount of interest has been focused on the development of ligand-free Suzuki-Miyaura reaction systems, which have the advantages of low cost, mild reaction conditions, and easy operation. So far, a number of ligand-free Suzuki-Miyaura reaction systems have been developed by using simple palladium salts, nanopalladium, or supported palladium catalysts. In this account, we will review our recent research on the oxygen-promoted ligand-free Suzuki-Miyaura reaction. Interestingly, the oxygen-promoting effect has been observed in different reaction media, including polyethylene glycol, organic/water mixed solvents and pure water. The oxygen-promoted reaction systems demonstrate high efficiency for the construction of biaryls.