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Indexed by:期刊论文

Date of Publication:2011-02-21

Journal:ORGANIC & BIOMOLECULAR CHEMISTRY

Included Journals:SCIE、EI、PubMed、Scopus

Volume:9

Issue:4

Page Number:1054-1060

ISSN No.:1477-0520

Abstract:A simple and efficient protocol has been developed for the PdCl2-catalyzed ligand-free and aerobic Suzuki reaction of aryl bromides or nitrogen-based heteroaryl bromides with arylboronic acids in good to excellent yields in aqueous ethanol. A systematic investigation on the effect of different atmospheres on the reactivity of the palladium-catalyzed Suzuki reaction has been carried out, the results show that an aerobic atmosphere demonstrates a positive effect on the reactivity of the Suzuki reaction in an aqueous media and a negative effect in a pure organic solvent, which exhibits that the water plays a crucial role for the function of the atmosphere on the palladium-catalyzed ligand-free Suzuki reaction.