Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2011-02-21

Journal: ORGANIC & BIOMOLECULAR CHEMISTRY

Included Journals: Scopus、PubMed、EI、SCIE

Volume: 9

Issue: 4

Page Number: 1054-1060

ISSN: 1477-0520

Abstract: A simple and efficient protocol has been developed for the PdCl2-catalyzed ligand-free and aerobic Suzuki reaction of aryl bromides or nitrogen-based heteroaryl bromides with arylboronic acids in good to excellent yields in aqueous ethanol. A systematic investigation on the effect of different atmospheres on the reactivity of the palladium-catalyzed Suzuki reaction has been carried out, the results show that an aerobic atmosphere demonstrates a positive effect on the reactivity of the Suzuki reaction in an aqueous media and a negative effect in a pure organic solvent, which exhibits that the water plays a crucial role for the function of the atmosphere on the palladium-catalyzed ligand-free Suzuki reaction.