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论文类型：期刊论文

发表时间：2015-01-01

发表刊物：CHINESE CHEMICAL LETTERS

收录刊物：SCIE、ISTIC、CSCD

卷号：26

期号：1

页面范围：55-57

ISSN号：1001-8417

关键字：Pyridine N-oxides; Arylation; Palladium; Suzuki reaction; Water

摘要：We report a practical and highly efficient protocol for the arylation of pyridine N-oxides with arylboronic acid through palladium-catalyzed Suzuki reaction in water. This ligand-free Suzuki reaction is performed in the presence of diisopropylamine and gives 2- or 3-arylated pyridyl N-oxide derivatives in good to excellent yields within 1 h. (C) 2014 Chun Liu. Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. All rights reserved.