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论文类型：期刊论文

发表时间：2020-06-01

发表刊物：ELECTROPHORESIS

收录刊物：PubMed、SCIE

卷号：41

期号：10-11,SI

页面范围：883-890

ISSN号：0173-0835

关键字：Feedback control; Fractional-order model; Generation of dynamic biochemical signals; Microfluidics; Programmable pump

摘要：The generation of dynamic biochemical signals in a microfluidic control system is of importance for the study of the interaction between biological cells and their niches. However, most of microfluidic control systems are not able to provide dynamic biochemical signals with high precision and stability due to inherent mechanical vibrations caused by the actuators of the programmable pumps. In this paper, we propose a novel microfluidic feedback control system integrating an external feedback control system with a Y-shaped microfluidic chip with a "Christmas tree" inlet. The Proportional Integral Derivative (PID) controller is implemented to reduce the influence of vibrations. In order to regulate the control parameters efficiently, a mathematical model is built to describe the actuator of the programmable pump, in which a fractional-order model is utilized. Both simulation and experimental studies are carried out, confirming that the microfluidic feedback control system can precisely and stably generate desired dynamic biochemical signals.