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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：女
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：化学工程
办公地点：大连理工大学西部校区化工实验楼D段305室
联系方式：130-1948-9068（手机）
电子邮箱：dujian@dlut.edu.cn
Asymmetric Direct alpha-Hydroxylation of beta-Oxo Esters by Phase-Transfer Catalysis Using Chiral Quaternary Ammonium Salts
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论文类型：期刊论文
发表时间：2010-12-01
发表刊物：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
收录刊物：SCIE、Scopus
期号：34
页面范围：6525-6530
ISSN号：1434-193X
关键字：Asymmetric catalysis; Phase-transfer catalysis; Hydroxylation; beta-Oxo esters
摘要：The first enantioselective direct alpha-hydroxylation of beta-oxo esters was developed by using phase-transfer catalysis. 1-Indanone-derived 1-adamantyl (1-Ad) beta-oxo esters, in the presence of commercially available cumyl hydroperoxide and a cinchonine-based ammonium salt, resulted in the corresponding products with 69-91% yield and 65-74% ee. The reaction had also been successfully scaled-up to a gram quantity, and a similar yield was obtained without loss of the enantioselectivity.