冯延宾，大连理工大学生物工程学院副教授，先后学习和工作于南开大学，中科院大连化物所。研究方向为结合结构生物学、生物信息学、分子标记及智能设计方法，尤其通过蛋白及配体的双维适配与分子共进化，研究天然及非天然产物生物催化合成路径、二氧化碳固定脱羧（羧化）关键酶的催化机制及理性设计改造。研究成果发表于ACS Catalysis, ACS Chemical Biology, J Biol Chem, Bioresource Technology, JAFC, Metabolic Engineering等SCI期刊。

近期研究成果：

Wang, Y., Wang, M., Li, X., Che, X., Cao,X., Ren, J., Feng, Y., Xue, S., (2026) Structure-guided ancestral evolution of HmfF yields a robust decarboxylase for terephthalic acid degradation, Journal of Agricultural and Food Chemistry.

Li, S., Hu, X., Che, X., Quan, L., Li, X., Feng, T., ... Feng Y.& Xue, S. (2026). Unveiling a catalytically promiscuous feruloyl esterase from Clostridium acetobutylicum，Applied Microbiology and Biotechnology

Wang, M., Wang, Y., Huang, H., Cao, X., Ren, J., Feng, Y., & Xue, S. (2025). Continuous site mutagenesis of fatty acid photodecarboxylase enables a highly thermostable enzyme for co-solvent-free decarboxylation. Bioresource Technology, 132683. 

Feng, T., Huang, H., Xu, Y., Che, X., Wang, M., Tao, X., ... Feng, Y.,& Xue, S. (2025). Multisite synergistic evolution of oleate hydratase via DCCM and the orthogonal location of distal sites. International Journal of Biological Macromolecules, 144001. 

Feng, Y., Wang, N., Cao, Q., Li, S., Xu, Y., Che, X., ... & Xue, S. (2025). Structural Insights into Trehalose-6-Phosphate Phosphorylase and Its Role in Trehalose 6-Phosphate Biosynthesis via a Multienzyme Cascade. Journal of agricultural and food chemistry, 73(30), 19065-19075.

Zhu, X., Feng, Y., Wang, M., Li, S., Li, H., Liu, L., & Xue, S. (2025). Integrated strategies for engineering ferulic acid decarboxylase with tunnel conformation and substrate pocket for adapting non-natural substrates. Biochemical Engineering Journal, 213, 109566. 

Che, X., Tao, X., Chen, J., Feng, Y., Cui, Z., Feng, T., ... Feng, Y.,& Xue, S. (2025). Mining Highly Active Oleate Hydratases by Structure Clustering, Sequence Clustering, and Ancestral Sequence Reconstruction. Journal of Agricultural and Food Chemistry, 73(12), 7335-7346. 

Li, X., Huang, H., Yuan, Y., Wang, M., Cao, X., Feng, Y., & Xue, S. (2025). Enhancing CO2 fixation catalyzed by salicylic acid decarboxylase with remodeled tunnels. International Journal of Biological Macromolecules, 148584.

Feng, Y., Li, H., Xu, Y., Zhu, X., Li, X., Ren, J., ... & Xue, S. (2024). Engineering the substrate channeling interface between the heterologous modules for a highly efficient FAD synthetase. Biochemical Engineering Journal, 209, 109365. 

Shi, J., Fan, Y., Jiang, X., Li, X., Li, S., Feng, Y., & Xue, S. (2024). Efficient synthesis of L-malic acid by malic enzyme biocatalysis with CO2 fixation. Bioresource Technology, 403, 130843.

相关授权专利：

1.一种合成海藻糖-6-磷酸的多酶体系及其应用，发明专利授权号 ZL202411325552.X 

2.一种阿魏酸脱羧酶高活性组合突变体的构建及其应用，发明专利授权号 ZL202411453598.X 

3.一种基于连续位点组合突变提升酶热稳定性的方法及其应用， 发明专利授权号 ZL202411439579.1 

4.一种基于祖先序列重建的呋喃二甲酸脱羧酶及其应用，发明专利授权号 ZL202510826873.6 

5.一种高效供给阿魏酸脱羧酶的辅因子prFMN的工程菌及构建方法与应用，发明专利授权号ZL202211358436.9 

6.一种阿魏酸脱羧酶高活性突变体及其应用，发明专利授权号ZL 202411453598.X