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论文类型：期刊论文

发表时间：2017-06-01

发表刊物：APPLIED MATHEMATICAL MODELLING

收录刊物：SCIE、EI

卷号：46

页面范围：554-571

ISSN号：0307-904X

关键字：Nonlinear time-delayed switched system; Biological robustness; Parallel optimization; Batch culture; Convergence analysis

摘要：In this paper, a nonlinear enzyme-catalytic time-delayed switched dynamical system is considered to describe batch culture of glycerol bioconversion to 1,3-propanediol induced by Klebsiella pneumoniae. This system can not only predict the exponential growth phase but also the lag and the stationary growth phases of batch culture since it contains two switching times for representing the starting moment of lag growth phase and the time when the cell specified growth rate reaches the maximum. The biological robustness is expressed in terms of the expectation and variance of the relative deviation. Our aim is to identify the switching times. To this end, a robust parameter identification problem is formulated, where the switching times are decision variables to be chosen such that the biological robustness measure is optimized. This problem, which is governed by the non-linear system, is subject to a quality constraint and continuous state inequality constraints. Using a hybrid time-scaling transformation to parameterize the switching times into new parameters, an equivalently robust parameter identification problem is investigated. The continuous state inequality constraints are approximated by a conventional inequality constraint, yielding a sequence of approximate robust parameter identification subproblems. The convergence analysis of this approximation is also investigated. Owing to the highly complex nature of these subproblems, a parallel algorithm, based on simulated annealing, is proposed to solve these subproblems. From an extensive simulation study, it is observed that the obtained optimal switching times are satisfactory. (C) 2017 Elsevier Inc. All rights reserved.