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论文类型：期刊论文
发表时间：2015-09-01
发表刊物：IEEE Transactions on NanoBioscience
收录刊物：EI、Scopus
卷号：14
期号：6
页面范围：660-667
摘要：Deterministic lateral displacement (DLD) arrays containing shaped pillars have been found to be more effective in biomedical sample separation. This study aims to numerically investigate the interplay between particles and microfluidic arrays, and to find out the key factors in determining the critical size of a DLD device with shaped pillars. A new formula is thus proposed to estimate the critical size for spherical particle separation in this kind of new DLD microfluidic arrays. The simulation results show that both rectangular and I-shaped arrays have considerably smaller critical sizes. The ratio of sub-channel widths is also found to play an important role in reducing the critical sizes. This paves a valuable way toward designing high-performance DLD microfluidic arrays. ? 2002-2011 IEEE.