Identification of the Apoptosis and Autophagy Bi-functional Proteins
Release time:2019-07-01
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Journal Papers
First Author:
Wang Peiran
Co-author:
Zhang Zhichao
Date of Publication:
2019-05-23
Journal:
Molecular informatics
Included Journals:
PubMed
Document Type:
J
ISSN No.:
1868-1751
Key Words:
PPI network analysis,apoptosis,autophagy,bi-functional proteins
Abstract:
Although autophagy and apoptosis, two main kinds of programmed cell death, constitute distinct cellular processes with often opposing outcomes, there have been shown a complex interplay between them in recent years. This interplay is surely critical to the overall fate of the cell. However, a full-scale identification of those bi-functional proteins involved in both functions is currently beyond reach by existing databases or traditional biological experiments. And that makes the interplay impossible to be well understood. Here we built a large, comprehensiveness apoptosis and autophagy related PPI (protein-protein interaction) network and then used topology clustering to undergo a network analysis workflow. Finally, we concluded a list of 151 apoptosis and autophagy bi-functional proteins from this network. By this way we showed a global view on these bi-functional proteins about their unique characteristics and provided clues of new functions of some proteins which are not focused in present researches.© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Translation or Not:
no
