Date of Publication:2022-10-10

Journal:Huagong Jinzhan/Chemical Industry and Engineering Progress

Volume:40

Issue:2

Page Number:977-989

ISSN No.:1000-6613

Abstract:Crystallization mechanism and morphology control is a critical concern for the crystal engineering study and relevant application. For example, urate crystallization is important for the study of gout induced by hyperuricemia. Herein, using PP membrane as a base membrane, 8 kinds of hydrogel composite membranes (HCMs) with different polymer composition were prepared by ultraviolet cross-linking method, and PEGDA-NIPAM hydrogel materials with excellent interface induced crystallization performance were selected for continuous optimization. Based on the comprehensive analysis of the reproducibility of the hydrogel preparation process and the results of NaCl droplet evaporation experiments, PEGDA-NIPAM (molar ratio is 2:1) material was used to prepare hydrogel slices (HGS). This type of HGS had a uniform surface, vertical structure and thickness, and the slice quality can be quantified by the surface area. Studies on the NaCl salt dissolution adsorption-crystallization experiment illustrated that the prepared HGS possesses hybrid pH-temperature responsibility for high-efficiency interfacial nucleation and concentration regulation functions, which can be used as a functional micro-platform to control solution crystallization. HGS was introduced into the mixed crystal slurry of uric acid dihydrate crystals (UAD) and simulated body fluids (SBF) to adjust the crystallization process and crystal morphology of sodium urate monohydrate crystals (MSUM). Studies showed that the addition of HGS can strengthen the crystal conversion process, and the crystallization duration was shortened from 72h to 20h. At the same time, HGS can also promote crystal growth and crystal agglomeration. Diverse crystal morphologies can be obtained in an efficient manner, which entirely distinguished from the one prepared via no-HGS. This work explored a new path for further revealing and developing crystal morphology control with hydrogel interfacial materials. © 2021, Chemical Industry Press Co., Ltd. All right reserved.

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