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论文类型：期刊论文

发表时间：2013-02-15

发表刊物：APPLIED MATHEMATICS AND COMPUTATION

收录刊物：SCIE、EI、Scopus

卷号：219

期号：12

页面范围：6979-6985

ISSN号：0096-3003

关键字：Nonlinear bilevel multi-stages dynamic system; Microbial fermentation; Parameter identification; Robustness of system; Nonlinear programming

摘要：In this paper, based on the microorganism batch fermentation of glycerol to 1,3-propanediol, we study a kind of nonlinear multi-stage dynamic system for the batch fermentation and its properties. Since it is difficult to measure the concentration of intracellular substance so far, we quantitatively describe robustness according to the basic features of biological systems. Taking experimental data of the concentration of extracellular substance and robustness as the performance index, we establish identification model of dynamic system for the batch fermentation. Then, its identifiability, the existence and continuity with respect to the parameters of the solution have been discussed. We decompose the identification problem into bilevel multi-stage optimal control subproblem, and both of them are equivalent. This work is a theoretical foundation of further numerical calculation. (C) 2013 Elsevier Inc. All rights reserved.