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论文类型：期刊论文

发表时间：2021-01-10

发表刊物：ADVANCED SCIENCE

卷号：7

期号：23

关键字：biosensing; nanostructure; plasmonic sensors; signal enhancement; ultrasensitivity

摘要：Biomolecular detection at a low concentration is usually the most important criterion for biological measurement and early stage disease diagnosis. In this paper, a highly sensitive nanoplasmonic biosensing approach is demonstrated by achieving near-infrared plasmonic excitation on a continuous gold-coated nanotriangular array. Near-infrared incident light at a small incident angle excites surface plasmon resonance with much higher spectral sensitivity compared with traditional configuration, due to its greater interactive volume and the stronger electric field intensity. By introducing sharp nanotriangular metallic tips, intense localization of plasmonic near-fields is realized to enhance the molecular perception ability on sensing surface. This approach with an enhanced sensitivity (42103.8 nm per RIU) and a high figure of merit (367.812) achieves a direct assay of ssDNA at nanomolar level, which is a further step in label-free ultrasensitive sensing technique. Considerable improvement is recorded in the detection limit of ssDNA as 1.2 x 10(-18)mbased on the coupling effect between nanotriangles and gold nanoparticles. This work combines high bulk- and surface-sensitivities, providing a simple way toward label-free ultralow-concentration biomolecular detection.