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论文类型：期刊论文

发表时间：2018-01-10

发表刊物：Current medicinal chemistry

收录刊物：SCIE、PubMed

卷号：25

期号：28

页面范围：3319-3332

ISSN号：1875-533X

关键字：cancer therapy,co-delivery,drug,gene,liposomes,synergistic effects.

摘要：There are several mechanisms by which cancer cells form resistance to treatments, including increasing anti-apoptosis, increasing drug efflux, inducing angiogenesis, enhancing DNA repair and altering cell cycle checkpoints, etc. The drugs are hard to reach the curative effects due to these resistance mechanisms. It has been suggested that liposomes based co-delivery systems, which can deliver drugs and genes to the same tumor cells and exhibit synergistic anti-cancer effects, could be used to overcome the resistance of cancer cells. Because the co-delivery systems could simultaneously block two or more pathways, that might promote the death of cancer cells by sensitizing cells to death stimuli. This article provides a brief review on the liposomes based co-delivery systems to overcome cancer resistance by the synergistic effects of drugs and genes. Particularly, the synergistic effects of combinatorial anti-cancer drugs and genes in various cancer models employing multifunctional liposomes based co-delivery systems have been discussed. This review also gives new insights into the challenges of liposomes based co-delivery systems in the field of cancer therapy, by which we hope to provide some suggestions on the development of liposomes based co-delivery systems. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.