点击次数：

论文类型：期刊论文

发表时间：2014-12-01

发表刊物：JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY

收录刊物：SCIE

卷号：80

期号：3-4

页面范围：383-390

ISSN号：0923-0750

关键字：1,8-Naphthalimide; o-N-Butylbenzene-1,2-diamine; Fluorescence; Probe; Copper ion; Live cells imaging

摘要：A fluorescent probe LZ-N with naphthalimide as fluorophore and N-butylbenzene-1,2-diamine as a new recognition moiety for copper ion was designed and synthesized. The probe LZ-N exhibits high selectivity for Cu2+ ion in aqueous media (CH3CN:H2O = 1:1) over all the other metal ions in our study, more than 20-fold fluorescence enhancement by coordinating with Cu2+, and the maximum emission intensity independence in the range of pH 2.06-9.25. The results of H-1-NMR titration, time-resolved fluorescence decay measurement, and computational optimization illuminate the mechanisms of Cu2+ and probe LZ-N. Confocal fluorescence images and cell viability values test show the high fluorescence enhancement of probe LZ-N for exogenous Cu2+ in living cells.