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论文类型：期刊论文

发表时间：2010-11-01

发表刊物：CHEMICAL RESEARCH IN CHINESE UNIVERSITIES

收录刊物：SCIE、ISTIC、CSCD、Scopus

卷号：26

期号：6

页面范围：981-985

ISSN号：1005-9040

关键字：Liver microsome; Reduction; Nitroaromatic compound; Aromatic hydroxylamine

摘要：Nitroaromatic compounds were reductively metabolized to the corresponding amine compounds via the intermediate hydroxylamines by liver microsomes from pig, rat, chook, cattle, sheep, paralichthys olivaceus and cyprinoid in varied reactivity. Similar with baker's yeast, the pig, rat and sheep liver microsomes exhibited high reactivity toward 4-nitro-1,2-dicyanbenzen(1a), while the cyprinoid liver microsomes were inefficient. Contrasted to compound la, monocyannitrobenzene(2a) was difficult to reduce by pig liver microsomes. In opposition to grape cells, pig liver microsomes exhibited activities toward some aromatic hydroxylamine compounds.