点击次数：

论文类型：期刊论文

发表时间：2015-10-01

发表刊物：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

收录刊物：SCIE、PubMed、Scopus

卷号：25

期号：19

页面范围：4078-4081

ISSN号：0960-894X

关键字：Chlorin derivatives; Chlorin e6; Photo cytotoxic activity; Singlet oxygen

摘要：Nine new chlorin derivatives containing maleimide functional group and amino acid residue with chlorin e6 scaffold (compounds 1-6) or pheophorbide a scaffold (compounds 7-9) were synthesised from chlorophyll a. The all nine derivatives demonstrated increased photo cytotoxic activity in HepG2 cell (IC50 3.2-20.5 mu M) comparing with chlorin e6 and its trimethyl ester. Their photo cytotoxicities were approximately dependent on their abilities to produce singlet oxygen (O-1(2)) in the cells. (C) 2015 Published by Elsevier Ltd.