梁智慧，副教授，博士生导师，硕士生导师。2017年于大连理工大学化学工程与工艺（化学工程）专业获得学士学位；2022年于大连理工大学化学工程专业获得博士学位，师从孙冰冰教授；2022-2025年于香港中文大学生物医学工程系（Department of Biomedical Engineering，CUHK）开展博士后研究工作，合作导师 Chung Hang Jonathan Choi 教授，博士后期间获得香港中文大学研资局（RGC）博士后研究奖学金项目（Postdoctoral Fellowship Scheme）为期三年的研究资助；2025年11月全职回国加入大连理工大学化工学院。

      主要研究方向包括疫苗佐剂的工程设计、纳米递送体系构建与疾病防治应用。重点围绕疫苗开发与实际应用中的“卡脖子”工程问题展开研究，深度聚焦于佐剂材料精准设计、抗原递送与稳定性调控、免疫调控规律与体内外作用机制揭示，旨在推动纳米疫苗技术与疾病防治领域的研究创新与技术应用转化。相关研究结合化学工程、材料化学、界面化学与免疫学等多学科交叉研究方法，实现了材料精准设计、机制深度解析及纳米佐剂技术突破。研究成果先后发表于Advanced Materials、Biomaterials、Nano Today、Nanoscale、Journal of Colloid and Interface Science、Vaccine、Frontiers in Immunology等生物材料、纳米材料科学、疫苗技术领域国际知名期刊，共计20余篇，累计影响影子超100，SCI 他引近千次，已获授权专利4项。参与国家重点研发计划项目及多项国家自然科学基金项目。

招生招聘信息：

      热烈欢迎具有化工、材料、生物、人工智能等专业背景的学生加入课题组，攻读硕士、博士学位！团队将提供优质的科研环境以及与国内知名企业交流的机会，鼓励在读硕士生、博士生参加国内外学术会议，开拓眼界。课题组长期致力于本科生科研培养，包括大学生创新创业计划项目、本研贯通、拔尖计划等，期待各位同学与我们联系！

      团队长期诚聘具有相关研究经验和背景的博士后科研人员加入团队，待遇优厚。有意者请将个人简历（教育背景、工作经历、发表论文情况等）发送至：zhliang@dlut.edu.cn，期待加入，共谋发展！

代表性论文如下：

1. Zhihui Liang, Hongyang Gao, Qian Ren, Xin Li, Yubin Ma, Changying Xue*, Bingbing Sun*, Suspension Stability of Aluminum-based Adjuvants, Nanoscale, 2025, 17, 17559-17567. 封面文章

2. Xin Wang, Haoyu Li, Chen Chen, Zhihui Liang*, Understanding of Endo/lysosomal Escape of Nanomaterials in Biomedical Application, Smart Molecules, 2025, e20240017.

3. Yu Xiao^#, Zhihui Liang^#, Moldir Shyngys, Aiana Baekova, Suen Cheung, Mathias Billy Muljadi, Qianqian Bai, Lula Zeng, Chung Hang Jonathan Choi*, In Vivo Interactions of Nucleic Acid Nanostructures with Cells, Advanced Materials, 2024, 37(2), 2314232.

4. Zhihui Liang, Hang Bao, Zhiying Yao, Min Li, Chen Chen, Lei Zhang, Huiyang Wang, Yiyang Guo, Yubin Ma, Xuecheng Yang, Ge Yu, Jiancheng Zhang, Changying Xue*, Bingbing Sun*, Chuanbin Mao*, The Orientation of CpG Conjugation on Aluminum Oxyhydroxide Nanoparticles Determines the Immunostimulatory Effects of Combination Adjuvants, Biomaterials, 2024, 308, 122569.

5. Zhiying Yao, Zhihui Liang, Min Li, Huiyang Wang, Yubin Ma, Yiyang Guo, Chen Chen, Changying Xue, Bingbing Sun*, Aluminum Oxyhydroxide-Poly(I:C) Combination Adjuvant with Balanced Immunostimulatory Potentials for Prophylactic Vaccines, Journal of Controlled Release, 2024, 10.1016/j.jconrel.2024.06.054.

6. Zhihui Liang^#, Yuan He^#, Christina SU Ieong, Chung Hang Jonathan Choi*, Cell-nano Interactions of Polydopamine Nanoparticles, Current Opinion in Biotechnology, 2023, 84, 103013.

7. Zhihui Liang, Xin Wang, Ge Yu, Min Li, Shuting Shi, Hang Bao, Chen Chen, Duo Fu, Wei Ma, Changying Xue, Bingbing Sun*, Mechanistic Understanding of the Aspect Ratio-Dependent Adjuvanticity of Engineered Aluminum Oxyhydroxide Nanorods in Prophylactic Vaccines, Nano Today, 2022, 43, 101445.

8. Shisheng Bi^#, Min Li^#, Zhihui Liang^#, Guangle Li, Ge Yu, Jiarui Zhang, Chen Chen, Cheng Yang, Changying Xue, Yi Y. Zuo, Bingbing Sun*, Self-Assembled Aluminum Oxyhydroxide Nanorices with Superior Suspension Stability for Vaccine Adjuvant, Journal of Colloid and Interface Science, 2022, 627, 238-246.

9. Min Li, Zhihui Liang, Chen Chen, Ge Yu, Zhiying Yao, Yiyang Guo, Lei Zhang, Hang Bao, Duo Fu, Xuecheng Yang, Huiyang Wang, Changying Xue, and Bingbing Sun*, Virus-Like Particle-Templated Silica-Adjuvanted Nanovaccines with Enhanced Humoral and Cellular Immunity, ACS Nano, 2022, 16(7), 10482-10495.

10. Ge Yu, Zhihui Liang, Zilan Yu, Min Li, Wenqi Yang, Yawei Zhang, Yuhang Zhao, Cheng Yang, Changying Xue, Li Shi, Bingbing Sun*, Engineering the Hydroxyl Content on Aluminum Oxyhydroxide Nanorod for Elucidating the Antigen Adsorption Behavior, npj Vaccines, 2022, 7, 62.

11. Chen Chen^#, Jingyun Wang^#, Zhihui Liang, Min Li, Duo Fu, Lei Zhang, Xuecheng Yang, Yiyang Guo, Dan Ge, Yang Liu, Bingbing Sun*, Monosodium Urate Crystals with Controlled Shape and Aspect Ratio for Elucidating the Pathological Progress of Acute Gout, Biomaterials Advances, 2022, 139, 213005.

12. Jiahuan Li, Ge Yu, Zhihui Liang, Min Li, Chen Chen, Xin Li, Yiyang Guo, Cheng Yang, Yang Liu, Caiqiao Zhang, Weiting Zhang, Jiaxu Liu, Xuehu Ma, Changying Xue, Bingbing Sun*, Mechanistic Elucidation of Freezing-Induced Surface Decomposition of Aluminum Oxyhydroxide Adjuvant, iScience, 2022, 25 (6), 104456.

13. Duo Fu, Mengjia Wang, Tao Yang, Min Li, Zhihui Liang, Chen Chen, Lei Zhang, Changying Xue, Bingbing Sun*, Chuanbin Mao*, Self-Assembled Flagella Protein Nanofibers Enhance Mucosal Immunity, Biomaterials, 2022, 288, 121733.

14. Min Li, Jiahuan Li, Yunlong Yang, Wenhui Liu, Zhihui Liang, Guanyu Ding, Xiaohe Chen, Qi Song*, Changying Xue*, Bingbing Sun*, Investigation of Mouse Hepatitis Virus Strain A59 Inactivation Under Both Ambient and Cold Environments Reveals the Mechanisms of Infectivity Reduction Following UVC Exposure, Journal of Environmental Chemical Engineering, 2022, 10, 107206, SCI: 000788128400007.

15. Zhihui Liang^#, Yun Yang^#, Ge Yu, Haoru Zhu, Xinyu Xia, Chen Chen, Duo Fu, Min Li, Gang Cheng, Changying Xue, Li Shi, Hao Zeng*, Bingbing Sun*, Engineered Aluminum Phosphate Nanoparticles with Well-Controlled Surface Property as Effective Vaccine Adjuvants, Biomaterials, 2021, 275, 120960.

16. Lei Zhang, Zhihui Liang, Chen Chen, Xuecheng Yang, Duo Fu, Hang Bao, Min Li, Shuting Shi, Ge Yu, Yixuan Zhang, Caiqiao Zhang, Weiting Zhang, Changying Xue, Bingbing Sun*, Engineered Hydroxyapatite Nanoadjuvants with Controlled Shape and Aspect Ratios Reveal Their Immunomodulatory Potentials, ACS Applied Materials & Interfaces, 2021, 13(50), 59662-59672.

17. Zhihui Liang, Haoru Zhu, Xin Wang, Bo Jing, Zifan Li, Xinyu Xia, Hongwu Sun, Yun Yang, Weiting Zhang, Li Shi, Hao Zeng*, Bingbing Sun*, Adjuvants for Coronavirus Vaccines, Frontiers in Immunology, 2020, 11, 589833.

18. Jingjing Liang, Zongbin Zhao*, Yongchao Tang, Zhihui Liang, Lulu Sun, Xin Pan, Xuzhen Wang, Jieshan Qiu*, New Carbon Materials, 2020, 35(5), 522-530.

19. Shuting Shi, Zhihui Liang, Bingbing Sun*, Response to Comment on: Vaccine Adjuvants: Understanding the Structure and Mechanism of Adjuvanticity, Vaccine, 2020, 38(13), 2759.

20. Shuting Shi, Haoru Zhu, Xinyu Xia, Zhihui Liang, Xuehu Ma, Bingbing Sun*, Vaccine Adjuvants: Understanding the Structure and Mechanism of Adjuvanticity, Vaccine, 2019, 37 (24), 3167-3178. ESI高引文章